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SCIENTIFIC SCORE
Possibly Effective
Based on 42 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 Softgels
Serving Per Container: 60
Amount Per Serving
%DV
Calories
25
Total Fat
2.5 g
3%**
Total Fish Oil
2,600 mg
†
EPA (Eicosapentaenoic acid) Omega-3
750 mg
†
DHA (Docosahexaenoic acid) Omega-3
750 mg
†
DPA (Docosapentaenoic acid) Omega-3
150 mg
†
Top Medical Research Studies
9
DHA-PS promotes liver recovery
DHA-enriched phosphatidylserine ameliorates cyclophosphamide-induced liver injury via regulating the gut-liver axis.
Highly relevant to liver health
We investigated the potential of DHA-enriched phosphatidylserine (DHA-PS) in addressing liver injuries caused by cyclophosphamide in mice. By administering cyclophosphamide over five days, we created a model to simulate this liver damage. Following this, we treated the mice with different doses of DHA-PS for a week to see if it could help heal their livers.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
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9
DHA's Role in Liver Health
Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury.
Study highlights DHA's importance
We explored the impact of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on the health of our liver, especially regarding nonalcoholic fatty liver disease (NAFLD). Using a zebrafish model with a specific mutation that prevents the production of DHA, we aimed to understand how this absence affects liver lipid balance and overall liver health.
Our findings revealed that without sufficient DHA, the liver showed increased fat storage and issues with fat processing. Instead of breaking down fats as it should, the liver was overwhelmed with lipids, leading to the telltale signs of NAFLD. Additionally, we noted that the liver cells in our mutated model were suffering from structural damage and stress, primarily through a process known as ferroptosis—rather than the more commonly known apoptosis.
Interestingly, when we supplemented these fish with DHA through diet or genetic modifications, we observed a remarkable improvement in liver health. This suggests that maintaining proper levels of DHA is crucial for preventing fatty liver disease and protecting liver cells from damage.
Our findings revealed that without sufficient DHA, the liver showed increased fat storage and issues with fat processing. Instead of breaking down fats as it should, the liver was overwhelmed with lipids, leading to the telltale signs of NAFLD. Additionally, we noted that the liver cells in our mutated model were suffering from structural damage and stress, primarily through a process known as ferroptosis—rather than the more commonly known apoptosis.
Interestingly, when we supplemented these fish with DHA through diet or genetic modifications, we observed a remarkable improvement in liver health. This suggests that maintaining proper levels of DHA is crucial for preventing fatty liver disease and protecting liver cells from damage.
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9
DPA protects against liver disease
Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice.
Strong evidence for DPA's benefits
We observed how docosapentaenoic acid (DPA) supplementation can impact liver health in mice fed a high-fat diet. The study involved 4-month-old male C57BL/6J mice, where it was found that those on a high-fat diet showed signs of fatty liver, obesity, and insulin resistance after just six weeks. However, when they were given DPA, interesting changes occurred.
The results revealed that DPA not only prevented the development of fatty liver but also kept serum cholesterol and glucose levels in check. It significantly improved insulin resistance, which was not the case for eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). Additionally, DPA helped maintain healthy levels of a hormone called adiponectin, which is crucial for metabolic health.
Furthermore, DPA supplementation also reduced increased liver enzyme levels, suggesting fewer inflammation and damage to the liver. These impressive benefits seem to stem from DPA's unique ability to influence important pathways in the liver that control fat production and inflammation.
Overall, it appears that DPA stands out in providing liver protection against the negative effects of a high-fat diet, making it a noteworthy contender in the fight against liver disease.
The results revealed that DPA not only prevented the development of fatty liver but also kept serum cholesterol and glucose levels in check. It significantly improved insulin resistance, which was not the case for eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). Additionally, DPA helped maintain healthy levels of a hormone called adiponectin, which is crucial for metabolic health.
Furthermore, DPA supplementation also reduced increased liver enzyme levels, suggesting fewer inflammation and damage to the liver. These impressive benefits seem to stem from DPA's unique ability to influence important pathways in the liver that control fat production and inflammation.
Overall, it appears that DPA stands out in providing liver protection against the negative effects of a high-fat diet, making it a noteworthy contender in the fight against liver disease.
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Most Useful Reviews
8.8
Lowers triglycerides
I use this product to reduce triglycerides and fat linked to liver disease. I take three capsules as per nutritional advice for three months each year. When my blood tests show increased liver fat, I recommence taking omega 3, focusing on DHA.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 42 Researches
7.5
9
Eicosapentaenoic acid aids liver health
Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
Moderate relevance to liver disease
We explored the effectiveness of eicosapentaenoic acid (EPA), a key component of Antarctic krill oil, in battling obesity and its associated liver issues. Our investigation specifically aimed to understand how EPA influences cholesterol levels and overall liver health, especially in the context of diet-induced obesity.
Using a mouse model and analyzing various molecular pathways, we observed that a high-fat diet led to increased oxidative stress and obesity-related indicators, which are harmful to liver function. However, the introduction of EPA showed promising results in reducing oxidative stress, fat accumulation, and improving key metabolic parameters. These improvements were linked to better cholesterol management and support for liver health.
The findings suggest that EPA might serve as a valuable intervention for those struggling with obesity-related liver disease. By enhancing cholesterol metabolism and addressing oxidative stress, EPA could play a role in the prevention and treatment of these conditions. Overall, our results indicate a potential pathway for therapeutic applications in liver health through EPA supplementation.
Using a mouse model and analyzing various molecular pathways, we observed that a high-fat diet led to increased oxidative stress and obesity-related indicators, which are harmful to liver function. However, the introduction of EPA showed promising results in reducing oxidative stress, fat accumulation, and improving key metabolic parameters. These improvements were linked to better cholesterol management and support for liver health.
The findings suggest that EPA might serve as a valuable intervention for those struggling with obesity-related liver disease. By enhancing cholesterol metabolism and addressing oxidative stress, EPA could play a role in the prevention and treatment of these conditions. Overall, our results indicate a potential pathway for therapeutic applications in liver health through EPA supplementation.
Read More
9
Tyrosol positively impacts liver health
Tyrosol regulates hepatic lipid metabolism in high-fat diet-induced NAFLD mice.
Relevant findings on liver disease
We conducted an intriguing study to explore the effects of tyrosol (TYR), a compound enriched with beneficial properties, on nonalcoholic fatty liver disease (NAFLD) in mice. Males of the C57BL/6J strain were divided into groups that received either a low-fat diet, a high-fat diet, or a high-fat diet supplemented with 0.025% TYR for 16 weeks.
Observations revealed that the mice consuming the TYR-enriched diet experienced a notable decrease in both final body weight and liver fat accumulation compared to those on just the high-fat diet. A closer examination of liver metabolites showed an increase in key substances, including eicosapentaenoic acid (EPA), which suggests that TYR positively influences lipid metabolism and supports liver health.
We further investigated the mechanism behind these benefits and found that TYR interacts with a receptor known as peroxisome proliferator-activated receptor-alpha (PPARα). This interaction is crucial in regulating liver lipid processing, helping to turn on the genes that promote better lipid management.
Overall, this compelling evidence indicates that TYR, particularly through its role involving EPA and PPARα, could be a promising dietary addition for alleviating fatty liver disease in contexts of poor diets. We are excited about these insights and their potential implications for improving liver health.
Observations revealed that the mice consuming the TYR-enriched diet experienced a notable decrease in both final body weight and liver fat accumulation compared to those on just the high-fat diet. A closer examination of liver metabolites showed an increase in key substances, including eicosapentaenoic acid (EPA), which suggests that TYR positively influences lipid metabolism and supports liver health.
We further investigated the mechanism behind these benefits and found that TYR interacts with a receptor known as peroxisome proliferator-activated receptor-alpha (PPARα). This interaction is crucial in regulating liver lipid processing, helping to turn on the genes that promote better lipid management.
Overall, this compelling evidence indicates that TYR, particularly through its role involving EPA and PPARα, could be a promising dietary addition for alleviating fatty liver disease in contexts of poor diets. We are excited about these insights and their potential implications for improving liver health.
Read More
9
Eicosapentaenoic Acid Reduces Hepatic Inflammation
Prevention of colitis-induced liver oxidative stress and inflammation in a transgenic mouse model with increased omega-3 polyunsaturated fatty acids.
Study suggests EPA's potential benefits
We explored the impact of eicosapentaenoic acid (EPA) and other omega-3 polyunsaturated fatty acids (n-3 PUFA) on liver inflammation related to inflammatory bowel disease (IBD). Using a transgenic mouse model known as fat-1 mice, we saw how increased levels of n-3 PUFA in tissues could play a role in reducing liver damage associated with colitis.
Our study pointed out that those fat-1 mice experienced less severe liver inflammation and oxidative stress compared to wild-type mice when subjected to a chemical that induces colitis. This is significant because while many discussions around omega-3 fatty acids center on their benefits for gut health, our findings suggest they also hold promise in addressing liver complications that might arise due to gut inflammation.
Additionally, we observed notable increases in certain beneficial metabolites derived from EPA, which are linked to reducing inflammation. These findings underline a strong connection between dietary n-3 PUFA intake and less oxidative stress in the liver, which could open up new avenues for therapeutic approaches in managing IBD and its systemic effects.
Our study pointed out that those fat-1 mice experienced less severe liver inflammation and oxidative stress compared to wild-type mice when subjected to a chemical that induces colitis. This is significant because while many discussions around omega-3 fatty acids center on their benefits for gut health, our findings suggest they also hold promise in addressing liver complications that might arise due to gut inflammation.
Additionally, we observed notable increases in certain beneficial metabolites derived from EPA, which are linked to reducing inflammation. These findings underline a strong connection between dietary n-3 PUFA intake and less oxidative stress in the liver, which could open up new avenues for therapeutic approaches in managing IBD and its systemic effects.
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9
DHA combined with MCTs beneficial
Cosupplementation with DHA and medium-chain triglycerides ameliorates NAFLD and reduces amyloid-β accumulation by modulating hepatic lipid metabolism in APP/PS1 mice.
Moderately relevant due to combination
We explored the effects of docosahexaenoic acid (DHA) on liver disease, specifically looking at its role in nonalcoholic fatty liver disease (NAFLD) and its potential connection to Alzheimer's disease. Our study conducted on APP/PS1 mice involved four groups of animals fed different diets—one with DHA, one with medium-chain triglycerides (MCTs), and one that combined both treatments.
Throughout the study, which lasted eight months, we observed a significant reduction in blood and liver lipids in the group that received both DHA and MCTs. This combination not only alleviated signs of NAFLD but also reduced the buildup of amyloid-β (Aβ), a protein linked to Alzheimer's, in the brain and serum.
Additionally, our findings indicated that DHA combined with MCTs improved the activity of liver enzymes critical for lipid metabolism. This suggests that these compounds together may enhance the liver's ability to clear fat and cholesterol while also increasing Aβ clearance.
While we noted the benefits of DHA, it's important to remember that the effects we observed were influenced by the combination with MCTs, making it challenging to pinpoint DHA's isolated impact. Still, our research provides valuable insight into how enhancing dietary fats could support liver health and potentially mitigate connections to neurodegenerative diseases.
Throughout the study, which lasted eight months, we observed a significant reduction in blood and liver lipids in the group that received both DHA and MCTs. This combination not only alleviated signs of NAFLD but also reduced the buildup of amyloid-β (Aβ), a protein linked to Alzheimer's, in the brain and serum.
Additionally, our findings indicated that DHA combined with MCTs improved the activity of liver enzymes critical for lipid metabolism. This suggests that these compounds together may enhance the liver's ability to clear fat and cholesterol while also increasing Aβ clearance.
While we noted the benefits of DHA, it's important to remember that the effects we observed were influenced by the combination with MCTs, making it challenging to pinpoint DHA's isolated impact. Still, our research provides valuable insight into how enhancing dietary fats could support liver health and potentially mitigate connections to neurodegenerative diseases.
Read More
9
Docosahexaenoic acid for liver cancer
APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage.
Examines DHA effectiveness in therapy
We explored the effectiveness of docosahexaenoic acid (DHA), particularly when delivered via nanoparticles, in treating liver disease, specifically hepatocellular carcinoma (HCC), in three rodent models. Our focus was on understanding how DHA affects HCC lesions as well as the performance of weighted amide proton transfer (APT) MRI as a monitoring tool.
In all three models—diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft, and human HepG2 ectopic xenograft—the APT MRI revealed higher signals from the cancerous tissue compared to surrounding normal tissue. Notably, in the DEN model, we found that the APT signal could effectively differentiate between malignant lesions and benign nodules.
After administering LDL-DHA nanoparticles directly into tumors, we observed a rapid decrease in APT signals within 72 hours, suggesting a promising therapeutic response. This trend was consistent in both N1S1 and HepG2 xenografts, indicating that DHA's effects, accelerated by nanoparticles, hold potential for therapeutic applications in liver cancer management.
Overall, our findings underscore the utility of APT imaging in the diagnostic and therapeutic landscapes of HCC, showcasing how innovative delivery methods can enhance treatment outcomes.
In all three models—diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft, and human HepG2 ectopic xenograft—the APT MRI revealed higher signals from the cancerous tissue compared to surrounding normal tissue. Notably, in the DEN model, we found that the APT signal could effectively differentiate between malignant lesions and benign nodules.
After administering LDL-DHA nanoparticles directly into tumors, we observed a rapid decrease in APT signals within 72 hours, suggesting a promising therapeutic response. This trend was consistent in both N1S1 and HepG2 xenografts, indicating that DHA's effects, accelerated by nanoparticles, hold potential for therapeutic applications in liver cancer management.
Overall, our findings underscore the utility of APT imaging in the diagnostic and therapeutic landscapes of HCC, showcasing how innovative delivery methods can enhance treatment outcomes.
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User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Lowers triglycerides
I use this product to reduce triglycerides and fat linked to liver disease. I take three capsules as per nutritional advice for three months each year. When my blood tests show increased liver fat, I recommence taking omega 3, focusing on DHA.
